Charlotte received her BSc in Physiotherapy in 1996 and worked for 11 years at the Department of Neurology, Akademiska sjukhuset, Uppsala University Hospital. From 2008 until 2014 she worked as a Lecturer in Physiotherapy at the Department of Neuroscience, Uppsala University. Since 2000 she has been responsible for Administration and Business Management at TdB Labs and became Chief Executive Officer in 2009.
Charlotte has ever since taken the company and her own business skills through one of the worlds best business incubators, Uppsala Innovation Center, and successfully completed a mini-MBA program. She worked in close collaboration with highly skilled professionals in business economy, sales, marketing, and quality assurance, and led the company from a GLP level to ISO 9001 certification in 2015. Charlotte has in 2018 become a certified coach through the International Coach Federation and her efforts have generated a sustainable leadership and business model for TdB Labs with the help of Sweden´s most active business developer, ALMI. Charlotte is also the Member of the Board in TdB Labs and has throughout the most recent years completed professional education in Board strategy and sustainable Board Work.
Charlotte has been given the lead of the company by the founder of TdB Labs Tony de Belder, and the enterprise has grown 3-fold since then, generating the highest reliability and quality reputation and winning several prizes and awards.
PhD Quality Assurance Manager
Gabriela received her Ph.D. from Tomas Bata University in Zlin in 2016 (Ph.D. thesis entitled ” Tailoring of polylactide properties and its degradation behaviour through various modification approaches”). After graduation, she worked as a R&D Manager and subsequently as a QC Manager at Aveflor, a.s. company based in Czech Republic. She joined TdB Labs in May 2019 as a Quality Controller responsible for compnay’s analytical methods and ensuring that the manufactured products hold the highest standard and are within required quality specifications. In March 2020, Gabriela became Quality Assurance Manager at TdB Labs.
MEng, PhD Senior Research Scientist
Raffaello holds a Chemical Engineering Diploma (2005) and a PhD degree in the field of physical organic chemistry (2010), both from the National Technical University of Athens, Greece. During his PhD, he specialized in the synthesis of solvatochromic probes and molecular switches. Later on, he moved to Marseille, France (September 2010–January 2013) working as a researcher at the Institute of Molecular Sciences, CNRS/Aix-Marseille University, in the field of water oxidation catalysts in the research group of Dr. Thierry Tron. Raffaello has subsequently moved to Uppsala University to join the group of Dr. Henrik Ottosson (2014) in which he worked as a PostDoc and later on as a researcher. His research interests revolve around physical organic and materials chemistry with an emphasis on the chemistry and photochemistry of graphene as well as polysaccharide chemistry. He is the author and co-author of 30 peer-reviewed scientific papers, three book chapters and has more than 35 contributions to international conference proceedings. Furthermore, Raffaello is an active referee of scientific peer-reviewed papers of world-class chemistry journals and he has acted repeatedly as a scientific expert evaluating international research grant proposals (including EU-grant applications). He has acted as the academic editor of a Book related to Dyes and Pigments and the Molecules (MDPI) issue: “Coupling Heterocyclic to Graphene Chemistry: Syntheses, Functionalizations, Interactions and Catalysis”. In his work at TdB Labs, Raffaello is particularly interested in polysaccharide fluorescent labeling and dye applications. Raffaello works currently as a senior research scientist at TdB Labs AB.
1. Hu Li, Raffaello Papadakis. “Click Chemistry Enabling Covalent and Non-Covalent Modifications of Graphene with (Poly)saccharides” Polymers 2021, 13, 142. DOI: 10.3390/polym13010142.
2. H Li, R Papadakis, T Hussain, A Karton, J Liu. Moiré patterns arising from bilayer graphone/graphene superlattice. Nano Res. 2020, 13, 1060–1064 DOI: 10.1007/s12274-020-2744-61.
3. Raffaello Papadakis* “Mono- and Di-Quaternized 4,4′-Bipyridine Derivatives as Key Building Blocks for Medium- and Environment-Responsive Compounds and Materials” Molecules, 2020, 25(1), 1; https://doi.org/10.3390/molecules25010001.
4. Hu Li*, Jingwei Liu, Raffaello Papadakis. “Direct measurement of the surface energy of single-walled carbon nanotubes through atomic force microscopy” J. App. Phys. 2019, 126, 065105. DOI: 10.1063/1.5108935.
5. Raffaello Papadakis,* Ioanna Deligkiozi, Katarzyna Nowak. “Study of the preferential solvation effects in binary solvent mixtures with use of intensely solvatochromic azobenzene involving rotaxane solutes” J.Mol.Liq.2019, 274, 715–723. DOI: 10.1016/j.molliq.2018.10.164.
6. Jiangwei Liu, Song Chen, Raffaello Papadakis,* Hu Li* “Nanoresolution pattering of hydrogenated graphene by electron beam induced C-H dissociation”. Nanotechnology (IOP Science) 2018, 29 (41) 415304. DOI: 10.1088/1361-6528/aad651.
7. Hu Li, Raffaello Papadakis, S. Hassan. M. Jafri, Thomas Thersleff, Henrik Ottosson and Klaus Leifer* “Superadhesion of Graphene Nanoscrolls”. Communication Physics (Nature) 2018, 1, 44. DOI: 10.1038/s42005-018-0043-2.
8. Jiangwei Liu, Song Chen, Raffaello Papadakis, Hu Li* “Determination of surface energy of gold nanoparticles through atomic force microscopy. Experimental observation of size-dependent surface energy”Appl. Phys. Lett.2018, 113, 083108. DOI: 10.1063/1.5046736.
9. Maria-Chrysanthi Kafentzi,‡ Raffaello Papadakis,‡ Federica Gennarini, Amélie Kochem, Olga Iranzo, Yves Le Mest, Nicolas Le Poul, Thierry Tron, Bruno Faure, Marius Réglier, A. Jalila Simaan* “Electrochemical water oxidation and stereo-selective oxygen atom transfer mediated by a copper complex” Chem. Eur. J. 2018, 24, 5213-5224 DOI: 10.1002/chem.201704613.
10. Anna Lundstedt,‡ Raffaello Papadakis,‡ Hu Li,‡ Yuanyuan Han, Kjell Jorner, Joakim Bergman, Klaus Leifer, Helena Grennberg, Henrik Ottosson* “White-light photoassisted covalent functionalization of graphene using 2-propanol” Small Methods, 2017, 1, 1700214. DOI: 10.1002/smtd.201700214.
11. Rabia Ayub, Raffaello Papadakis, Kjell Jorner, Burkhard Zietz and Henrik Ottosson*“The Cyclopropyl Group: An Excited State Aromaticity Indicator?” Chem. Eur. J. 2017, 23, 13684–13695. DOI: 10.1002/chem.201701404.
12. Raffaello Papadakis*“Solute-centric versus indicator-centric solvent polarity parameters in binary solvent mixtures. Determining the contribution of local solvent basicity to the solvatochromism of ferrocyanide(II) dyes” J. Mol. Liq. 2017, 241, 211–221.DOI: http://dx.doi.org/10.1016/j.molliq.2017.05.147.
13. Raffaello Papadakis, Hu Li, Joakim Bergman, Anna Lundstedt, Kjell Jorner, Rabia Ayub, Burkhard Jahn, Soumyajyoti Haldar, Aleksandra Denisova, Burkhard Zietz, Roland Lindh, Biplab Sanyal, Helena Grennberg, Klaus Leifer and Henrik Ottosson* “Metal-Free Photochemical Silylations and Transfer Hydrogenations of Benzenoid Hydrocarbons and Graphene” Nat. Commun. 2016, 7, 12962. DOI: 10.1038/ncomms12962.
14. Raffaello Papadakis* “Preferential solvation of a highly medium responsive pentacyanoferrate(II) complex in binary solvent mixtures. Understanding the role of dielectric enrichment and the specificity of solute-solvent interactions” J. Phys. Chem. B, 2016, 120, 9422−9433. DOI : 10.1021/acs.jpcb.6b05868.
15. Raffaello Papadakis,* Ioanna Deligkiozi, Michel Giorgi, Bruno Faure and Athanase Tsolomitis “Supramolecular complexes of non-symmetric viologens cations and hexacyanoferrate(II) anions. A spectroscopic and crystallographic study”. RSC Advances, 2016, 6, 575–585. DOI: 10.1039/C5RA16732A.
16. Raffaello Papadakis, Henrik Ottosson*“The excited state antiaromatic benzene ring: A molecular Mr. Hyde?” Chem. Soc. Rev. 2015, 44, 6472-6493. DOI: 10.1039/c5cs00057b. Part of themed collection: Challenges in Aromaticity: 150 Years after Kekulé’s Benzene.
17. Ioanna Deligkiozi, Evangelos Voyiatzis, Athanase Tsolomitis, Raffaello Papadakis* “Synthesis and characterization of new azobenzene-containing bis pentacyanoferrate(II) stoppered push-pull rotaxanes, with α- and β-cyclodextrin. Towards highly medium responsive dyes.” Dyes Pigment., 2015, 113, 709–722. DOI: 10.1016/j.dyepig.2014.10.005 (Highlighted on Advances in Engineering, April 2015)
18. Raffaello Papadakis*“The solvatochromic behavior and degree of ionicity of a synthesized pentacyano (N-sub-stituted-4,4′-bipyridinium) ferrate(II) complex in different media. Tuning the solvatochromic intensity in aqueous glucose solutions”. Chem. Phys., 2014, 430, 29–39. DOI: 10.1016/j.chemphys.2013.12.008.
19. Raffaello Papadakis Eric Riviere, Michel Giorgi, Pierre Rousselot-Pailley, Marius Réglier, Jalila A. Simaan* and Thierry Tron.“Structural and magnetic characterization of a tetranuclear copper(II) cubane stabilized by intra-molecular metal cation-π interactions” Inorg.Chem. 2013, 52, 5824-5830. DOI:10.1021/ic3027545.
20. Ioanna Deligkiozi, Raffaello Papadakis*, Athanase Tsolomitis “Photoconductive properties of a π-conjugated a-cyclodextrin containing rotaxane and its corresponding molecular dumbbell”. Phys. Chem. Chem. Phys. 2013, 15, 3497-3503. DOI: 10.1039/c3cp43794a.
21. Raffaello Papadakis*, Ioanna Deligkiozi and Athanase Tsolomitis. “Synthesis and characterization of a group of new medium responsive non symmetric viologens. Chromotropism and structural effects” Dyes Pigment. 2012, 95, 478-484. DOI: 10.1016/j.dyepig.2012.06.013.
22. Ioanna Deligkiozi, Raffaello Papadakis and Athanase Tsolomitis* “Synthesis characterization and photoswitchability of a new rotaxane of α-cyclodextrin with a diazobenzene containing π-conjugated molecular dumbbell” Supramol. Chem. 2012, 24, 333-343. DOI:10.1080/10610278.2012.660529
23. Raffaello Papadakis* and Athanase Tsolomitis. “Solvatochromism and preferential solvation in binary mixtures of hydroxylic and non hydroxylic solvents, of 4-pentacyanoferrate 4′-aryl substituted bipyridinium complexes” J. Solution Chem., 2011, 40, 1108-1125. DOI: 10.1007/s10953-011-9697-z.
24. Raffaello Papadakis, Ioanna Deligkiozi, and Athanase Tsolomitis*“Spectroscopic investigation of the solvatochromic behavior of a new synthesized non symmetric viologen dye. Study of the solvent-solute interactions” Anal. Bional. Chem. 2010, 397, 2253-2259. DOI: 10.1007/s00216-010-3792-7.
25. Raffaello Papadakis and Athanase Tsolomitis*“Study of the correlations of the MLCT Vis-absorption maxima of 4-pentacyanoferrate-4΄-aryl substituted bispyridinium complexes with the Hammett substituent parameters and the solvent polarity parameters ΕTN and AN” J. Phys. Org. Chem., 2009, 22, 515-521. DOI: 10.1002/poc.1514.
1. Raffaello Papadakis*, Ioanna Deligkiozi. “Solvent Effects in Supramolecular systems”Chapter in: Solvents and Solvent Effects. Editor Dr. Daniel Glossman-Mitnik (InTech–Open Science) DOI: 10.5772/intechopen.86981.
2. Raffaello Papadakis*, Ioanna Deligkiozi, Hu Li. “Photoconductive interlocked molecules and macromolecules”Chapter in: Photodiodes. Editor Prof. Kuan Chee (InTech – Open Science). DOI: 10.5772/intechopen.79798.
Ramesh Babu Namburi
MSc PhD Quality Controller
Ramesh Babu Namburi has extensive experience in structural and functional characterization of glycosaminoglycans (GAGs)/polysaccharides. Holding two master degrees, one in Marine Biotechnology from Andhra University, India from 2005, and the second in Applied Biotechnology from Uppsala University, Sweden from 2009, Ramesh received his PhD degree in biomedicine (Glycobiology) from Uppsala University in 2016. During his PhD Ramesh characterized highly sulfated polysaccharides and found their effect on cellular activities during wound healing and organ regeneration. He also characterized bacterial enzymes (sulfatases & lyases) that specifically cleave GAGs/polysaccharides. Ramesh has also worked as a researcher in 2017 for one year identifying a conserved gene sequence of polysaccharide-synthesizing enzymes. Ramesh has worked as production engineer in a German based Naturnova company in Srilanka. He received a diploma in Downstream Bioprocessing from GE healthcare (2019).
His research experience includes glycobiology, biochemistry, microbiology, immunology, cell & molecular biology and regenerative medicine. Ramesh has several scientific publications and have participated in national & international conferences on proteoglycans. Being specialized in characterization and analysis of GAGs/polysaccharides, Ramesh is responsible for all Quality Control analyses of products at TdB Labs since August 2020.
Ramachandra, R., Namburi, R. B., Dupont, S. T., Ortega-Martinez, O., van Kuppevelt, T. H., Lindahl, U., & Spillmann, D. (2017). A potential role for chondroitin sulfate/dermatan sulfate in arm regeneration in Amphiura filiformis. Glycobiology, 27(5), 438–449. https://doi.org/10.1093/glycob/cwx010
Namburi, R. B., Berteau, O., Spillmann, D., & Rossi, M. (2016). Chondroitinase AC: A host-associated genetic feature of Helicobacter bizzozeronii. Veterinary microbiology, 186, 21–27. https://doi.org/10.1016/j.vetmic.2016.02.013
Ulmer, J. E., Vilén, E. M., Namburi, R. B., Benjdia, A., Beneteau, J., Malleron, A., Bonnaffé, D., Driguez, P. A., Descroix, K., Lassalle, G., Le Narvor, C., Sandström, C., Spillmann, D., & Berteau, O. (2014). Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. The Journal of biological chemistry, 289(35), 24289–24303. https://doi.org/10.1074/jbc.M114.573303
Ramachandra, R., Namburi, R. B., Ortega-Martinez, O., Shi, X., Zaia, J., Dupont, S. T., Thorndyke, M. C., Lindahl, U., & Spillmann, D. (2014). Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling. Glycobiology, 24(2), 195–207. https://doi.org/10.1093/glycob/cwt100
Cerenius, L., Babu, R., Söderhäll, K., Jiravanichpaisal, P. (2010). In vitro effects on bacterial growth of phenoloxidase reaction products. Journal of Invertebrate Pathology, 103(1) 21-23. ISSN 0022-2011, https://doi.org/10.1016/j.jip.2009.09.006.
Gösta Naeslunds Minnesfond scholarship (2016).
MSc PhD Head of Chemistry
Edouard is an experienced synthetic organic and medicinal chemist who received his M.Sc in 1990 from Samara State University (Russia) in the field of carbohydrate chemistry. After moving to Uppsala, Sweden, he obtained his PhD in the Bioorganic Chemistry Department at Uppsala University (2000), with the doctoral thesis focusing on nucleoside chemistry and nucleic acids research.
Short thereafter Edouard has dedicated 14 years to Life Science industry working with preclinical drug discovery at Karo Bio AB (Stockholm, Sweden). During this time Edouard has developed novel ligands for nuclear receptors, contributing to medicinal chemistry programs in the areas of inflammation, diabetes, CNS and autoimmune disease. He was the manager and project leader for chemistry efforts in collaborative projects with world-leading pharma companies including Wyeth Pharmaceuticals (US), Zydus Cadila (India), Pfizer (US), among others.
Since 2015 he has been conducting research on antibacterial substances at the Medicinal Chemistry Department, Uppsala University (Sweden). Edouard’s main project within this role included the design and synthesis of novel antibiotics, and he was assigned as a Program Leader for UU antibacterial project named ENABLE (European Gram Negative Antibacterial Engine) – an European antibacterial drug discovery platform.
Edouard has joined TdB Labs in September 2020 as Head of Chemistry and is responsible to secure continuous chemical development, quality and sustainability of TdB Labs products and services.
Administrative and Sales Assistant B. Sc student
Sebastian is studying his first year at the bachelor’s programme in chemistry at Uppsala University. Besides his studies, he is also working as an Administrative and Sales Assistant at TdB Labs.
MSc, PhD Scientific Consultant
Alexander Paptchikhine received his B.Sc. from Samara State University (1979, Russia) and his PhD from Institute of Molecular Biology, Russian Academy of Science Moscow, (1987, Russia, Ph. D. thesis entitled “Synthesis of Carbohydrate Modified Nucleosides”). Alexander has been working in Samara State University (research assistant, senior scientist 6 years), BMC (Uppsala, Sweden, postdoc, research assistant, 1991-1995), Pharmacia, Biovitrum (Uppsala; Sweden, Scientist II, 1995-2009), AstraZeneca (Stockholm; Sweden, Scientist, 2010-2012), Karobio (Stockholm; Sweden, Scientist, 2013-2014). During this long scientific career in R & D he acquired experience:
in developing synthetic routes for novel carbohydrate and heterocycle- modified nucleosides as potential anti-cancer and anti-retro-viral agents as well as new methods for modifying carbohydrates;
in medicinal and combinatorial chemistry at all stages of project development – hit optimization, hit-to-lead and lead optimization (route development, scaffold synthesis, scale up, synthesis optimization, design and preparation of focused libraries for SAR build-up etc);
in chemical development in multiple projects. This included multi-step synthesis of Active Pharmaceutical Ingredients and active metabolites in multi gram scales; evaluation of existing routes provided by medicinal chemists and designing new synthetic routes if necessary;
in the chemistry of a wide range of classes of organic compounds (heterocycles, carbohydrates, guanidines, fluororganics, coupling chemistry etc).
Alexander joined TdB Labs AB in March 2015 as senior research scientist.
1. Synthesis of 3′-azido- and 3′-amino-3′-deoxyarabinonucleoside 5′-triphosphates and the investigation of their substrate properties in the systems with polynucleotide synthesizing enzymes. A.V. Papchikhin; P.P. Purygin; A.V. Azhajev; A.A. Krayevsky; T.V. Kutateladze; Z.G. Chidgavadze; R.Sh. Bibiblashvili; Bioorg. Chem., (Russia), 1985, 11, pp. 1367-1379
2. Inhibiting action of some analogues of nucleoside 5′-triphosphates on DNA synthesis catalyzed by polymerase of herprs simplex virus type 1. T.J. Kilesso; V.M. Shobukhov; A.V. Papchikhin; G.A. Galegov; Mol. Genetic, Microbiology and Virology, (Russia), 1987, N 10, pp. 41-44.
3. Inhibitory effect of 3′-amino- and 3′-azido-3′-deoxyribonucleoside 5′-triphosphates on RNA synthesis catalysed by influenza A viral RNA polymerase and cellular RNA polymerase. N.F. Pravdina; A.V. Papchikhin; P.P. Purygin; G.A. Galegov; Mol. Genetic, Microbiology and Virology, (Russia), 1989, N 1, pp. 29-33.
4. Selective inhibitors of DNA chain elongation catalysed by DNA polymerases. A.A. Krayevsky; M.K. Kukhanova; A.M. Atrazhev; N.B. Dyatkina; A.V. Papchikhin; Z.G. Chidgavadze; R.Sh. Bibiblashvili; Nucleosides and nucleotides 1988, 7(5&6), pp. 613-617
5. Conformationally restricted nucleoside 5′-triphosphates as termination substrates for DNA polymerases. Z.G. Chidgavadze; R.Sh. Bibiblashvili; T.A Rozovskaya; N.V. Tarusova; A.M. Atrazhev; N.B.Dyatkina; M.K Kukhanova; A.V. Papchikhin; A.A. Krayevsky; Mol. Biolog. (Russia), 1989, 23, pp. 1732-1742.
6. X-ray analysis of 2′,3′-lyxoanhydrothymidine, a conformationally restricted inhibitor of retroviral reverse transcriptases. G.V. Gurskaya; A.V. Bochkarev; A.S. Zdanov; A.V. Papchikhin; P.P. Purygin; A.A. Krayevsky; FEBS Letters, 1990, 265, pp. 63-66.
7. Structural features of 2′,3′-riboanhydroadenosine, a conformationaly restricted termination substrate of DNA polymerase. G.V. Gurskaya; A.V. Bochkarev; A.S. Zdanov; A.V. Papchikhin; P.P. Purygin; A.A. Krayevsky; Nucleosides and Nucleotides 1992, 11(1), pp. 1-9.
8. Synthesis of 2′,3′-dideoxy-3′-nitro-2′,3′-didehydrothymidine. Its use as a general intermediate for the preparation of various 2′,3′-substituted nucleosides. N. Hossain; A. Papchikhin; N. Garg; I. Federov; J. Chattopadhyaya; Nucleosides and Nucleotides, 1993, 12(5), pp. 499-528.
9. [4+2] and [3+2] cycloaddition reactions of 2′,3′-dideoxy-3′-nitro-2′,3′-didehydrothymidine with ethyl vinyl ether. A. Papchikhin; P. Agback; J. Plavec; J. Chattopadhyaya; J. Org. Chem., 1993, 58, pp. 2874-2879.
10. Solution and solid state structure of 2′,5′-bis-(O-trityl)-3′-oximinouridine. P. Agback; A. Papchikhin; S. Neidle; J. Chattopadhyaya; Nucleosides and Nucleotides, 1993, 12(6), pp. 605-614.
11. Synthesis of 2′- and 3′-spiro-isoxazolidine derivatives of thymidine and their conversion to 2′,3′-dideoxy-2′,3′-didehydro-3′-C-substituted nucleosides by radical promoted fragmentation. N. Hossain; A. Papchikhin; J. Plavec; J. Chattopadhyaya; Tetrahedron. 1993, 49, pp. 10133-10156.
12. New diastereospecific synthesis of 2′,3′-dideoxy-2′- or 3′-C2-branched- or 2′,3′-?-fused-isoxazolidine nucleosides directly from the seconucleoside. A. Papchikhin; J. Chattopadhyaya; Tetrahedron. 1994, 50, pp. 5279-5286.
13. How does the electronegativity of the substituent dictate the strength of the gauche effect? C. Thibaudeau; J. Plavec; N. Garg; A. Papchikhin; J. Chattopadhyaya; J. Am. Chem. Soc. 1994, 116, pp. 4038-4043.
14. 2′,3′-Dideoxy-3′-C,2′-N-[(3R,5R)-5-ethoxycarbonyl-2-methyl-1,2-isoxazolidine]ribothymidi-ne. B. M. Burkhart; A. Papchikhin; J. Chattopadhyaya; M. Sundaralingam. Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 1995, C51(7), 1462-4.
15. The diastereospecific synthesis of new 2′,3′-cis-?-fused carbocyclic nucleosides. A. Papchikhin; P. Agback; J. Plavec; J. Chattopadhyaya; Tetrahedron. 1995, 51, pp. 329-342.
16. 2′,3′-Dideoxy-3′-nitrothymidine and 2′-propoxy-3′-nitrothymidine. S. Neidle; J. Chattopadhyaya; N. Hossain; A. Papchikhin. Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 1996, C52(12), 3173-3177.
1. Substituted azolids of ribonucleoside 5′-monophosphates as intermediate products for the synthesis of ribonucleoside 5′-polyphosphates. Pat. USSR N 1491872. 1989. P.P. Purygin; A.A. Krayevsky; Z.P. Belousova; A.V. Papchikhin.
2. Synthesis of 2′-deoxyxylothymidine, derivatives of D-xylofuranose, and derivatives of xylothymidine. Pat. USSR 2108339 C1. 1998. A.V. Papchikhin, S.A Rumyantseva