Tetramethylrhodamine Hyaloronic Acid

Tetramethylrhodamine Hyaluronic Acid

Hyaluronic acid (HA) can be obtained from various sources, for example rooster combs or Streptococcus equi. We can supply derivatives of either of these qualities labelled with tetramethylrhodamine (T-HA). All batches are checked for molecular weight, degree of substitution, loss on drying and free TRITC. TdB Labs can produce T-HA with a molecular weight of approximately 6 MDa. T-HA is supplied as a pink powder.

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Structure
Hyaluronic acid is a polysaccharide composed of alternating β(1-3) glucuronide and β(1-4) glucosaminide units derived from Streptococcus equi. The hyaluronic acid is labelled with amino-tetramethylrhodamine. The degree of substitution lies between 0.001 and 0.008. The labelling procedures do not lead to depolymerisation of the HA.

Spectral data
T-HA has an excitation maximum at 552 nm and an emission maximum at 576 nm.

Storage and stability
T-HA is stable for more than 6 years when stored dry in well-sealed containers.

Solubility
T-HA dissolves readily in water.

Application
T-HA have been used to e.g. investigate invasive growth into brain tissue. Read more about applications here.

References

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All publications

  1. Pusch, A. et al. CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 1803, 261–274 (2010)
  2. Kaminski, T., Siebrasse, J.-P., Gieselmann, V., Kubitscheck, U., Kappler, J. Imaging and tracking of single hyaluronan molecules diffusing in solution. Glycoconjugate Journal 25(6), 555-560 (2008).

How to order

Visit our webshop to see the molecular weights and pack sizes available. Please send an e-mail to order@tdblabs.se if you would like to receive a quote, place a bulk order or if you wish to place your order manually.

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