CM-dextran can be used as a matrix component in order to prepare surfaces for cell adherence and culture. CM-dextran and CM-polysucrose from TdB Labs have been used in studies of magnetic nanoparticles targeted to cancer cells (1) and P-selectin (2), electrochemical immunoassays (3), regulation of scaffold cell adhesion (4) and enzyme immobilization (5) and more. CM-dextran can also be used for the construction of polymer membranes. Phenyl-dextran can use for coating of medical devices to impart a more hydrophilic character.
1. Ficko, B. W., NDong, C., Giacometti, P., Griswold, K. E. & Diamond, S. G. A Feasibility Study of Nonlinear Spectroscopic Measurement of Magnetic Nanoparticles Targeted to Cancer Cells. IEEE Transactions on Biomedical Engineering 64, 972–979 (2017).
2. Juenet, M. et al. Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156, 204–216 (2018).
3. Hwang, H. et al. MESIA: Magnetic force-assisted electrochemical sandwich immunoassays for quantification of prostate-specific antigen in human serum. Analytica Chimica Acta 1061, 92–100 (2019).
4. Burke, M. et al. Regulation of Scaffold Cell Adhesion Using Artificial Membrane Binding Proteins. Macromolecular Bioscience 17, 1600523 (2017).
5. Terentyeva, T. G. et al. Bioactive flake–shell capsules: soft silica nanoparticles for efficient enzyme immobilization. J. Mater. Chem. B 1, 3248–3256 (2013).
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