Drug delivery

Hydrogels involving dextran derivatives are seriously considered as matrices for the controlled release of drug molecules. Ongoing research aiming at improving the fabrication efficiency as well as the drug delivery capability of various anti-cancer drugs involves dextran derivatives as they exhibit high hydrogel formation capacity, low toxicity combined with high biocompatibility and biodegradability (1). Fluorescent dextran derivatives from TdB Labs have been used in hydrogel scaffolds (2) and for studying diffusion and drug delivery with hydrogels. Fluorescent dextran derivatives, blue dextran and other polysaccharides from TdB Labs have also been used to study drug delivery and drug release with microneedles arrays (3,4), drug loading features of nano-erythrocytes (5), biphasic pulsatile drug release (6) and more.

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References

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1. Thompson, S. T., Cass, K. H. & Stellwagen, E. Blue dextran-sepharose: an affinity column for the dinucleotide fold in proteins. PNAS 72, 669–672 (1975).
2. Grenier, J. et al. Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying. Acta Biomaterialia (2019) doi:10.1016/j.actbio.2019.05.070.
3. Larrañeta, E. et al. A facile system to evaluate in vitro drug release from dissolving microneedle arrays. International Journal of Pharmaceutics 497, 62–69 (2016).
4. Thakur, R. R. S. et al. Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery. Drug Deliv. and Transl. Res. 6, 800–815 (2016).
5. Dong, X. et al. Formulation and Drug Loading Features of Nano-Erythrocytes. Nanoscale Research Letters 12, 202 (2017).
6. Beugeling, M. et al. The mechanism behind the biphasic pulsatile drug release from physically mixed poly(dl-lactic(-co-glycolic) acid)-based compacts. International Journal of Pharmaceutics 551, 195–202 (2018).

 

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