The microcirculation can be described as the smallest circulation of blood in the smallest vessels, called microvessels (1). These are present within all organ tissues. Fluorescent dextran derivatives from TdB Labs have been used to study for the leukocyte adhesion and macromolecular leakage and the leakage of microcirculation during ischemia/reperfusion (2). The intestinal mucosal microcirculation have also been studied (3).
1. Jackson, W. F. Chapter 89 – Microcirculation. in Muscle (eds. Hill, J. A. & Olson, E. N.) 1197–1206 (Academic Press, 2012). doi:10.1016/B978-0-12-381510-1.00089-2.
2. Simões, C., Svensjö, E. & Bouskela, E. Effects of Cromakalim and Glibenclamide on Arteriolar and Venular Diameters and Macromolecular Leakage in the Microcirculation During Ischemia/Reperfusion. Journal of Cardiovascular Pharmacology 39, 340 (2002).
3. Schmidt, C. et al. Confocal laser endomicroscopy reliably detects sepsis-related and treatment-associated changes in intestinal mucosal microcirculation. Br J Anaesth 111, 996–1003 (2013).