TdB Labs Legacy

Our Legacy

Our Legacy

TdB Labs was founded by the dextran pioneer Dr. Tony de Belder in 1991. Before the company was started, Tony had a long career working in the department of research and development at Pharmacia, Uppsala.

Tony och Charlotte

When TdB Labs was founded, the company was first mostly a consultancy enterprise and was therefore called TdB Consultancy. Products for research and development in pharmaceuticals, diagnostics and biotech were introduced as the company grew. About 20 years ago, TdB Labs was involved in developing a dextran sulfate sodium (DSS) for inducing colitis, which has proved an invaluable tool for studying the causes and treatment of inflammation in the gut.

In 2009, TdB Labs moved to new premises in Uppsala Business Park and begun a period of expansion. At that time, Tony’s’ daughter Charlotte de Belder Tesséus, took over the role as CEO. Tony stays within the company as a Scientific Consultant and member of the Board. In 2019, the company changed name from TdB Consultancy to TdB Labs.

Tony de Belder

BSc PhD MRCS
Director, Scientific Consultant

Tony received his B.Sc. from University College London and thereafter continued on a PhD programme involving carbohydrate derivatives of ferrocene. After a series of post-docs. (Royal Holloway College, Univ. of London and Träforsknings Institute in Stockholm), he then began a long career in R & D at Pharmacia, Uppsala in a department devoted to applications of polysaccharides and their derivatives as pharmaceuticals. The research was mostly directed on dextran and dextran derivatives. This work naturally involved not only chemistry but also intimate contact with quality assurance and quality control, pharmacological and formulation issues including stability and bioassays.

In 1990, Tony started a consultancy company and began to market a limited range of products for research, in particular a special dextran sulphate fraction (known now as DSS) for research on ulcerous colitis. As a consultant, he worked extensively for Amersham Biosciences developing new dextran products and documentation. During this time he also helped major pharmaceutical, diagnostic and biotech. organisations in Sweden and abroad on diverse projects mostly involving dextran.

In 2009, the company moved to new premises in Uppsala Business Park and begun a period of expansion.

Tony is a Member of the Royal Society of Chemistry and has contributed extensively to scientific journals, reviews and encyclopedias on many aspects of carbohydrates but mostly dextran related topics. A selection of these publications is given below.

Publications

1. A.N.de Belder, E.J.Bourne and J.B.Pridham, ß-Glucopyranosides of Hydroxymethyl- and Hydroxyethyl-ferrocene, J.Chem.Soc., 1961, 879, 4464-4467.

2. A.N.de Belder, B.Lindberg and O.Theander, Partial methylation Studies on methyl ß-D-Glucopyranoside and some Derivatives, Acta Chem. Scand., 1962, 16, 2005-2009.

3. A.N.de Belder, P.J.Garegg, B.Lindberg et al., The Preparation of 2-tetrahydropyranyl ß-D-Glcopyranosides and methyl 4-(2-tetrahydropyranyl) –ß-D-glucopyanosides, Acta Chem. Scand., 1962, 16, 623-628.

4. A.N.de Belder, E.J.Bourne and H.Weigel, Studies on tert-butyl derivatives of D-Glucose, Carbohyd.Res.,1966, 3, 1-6.

5. A.N.de Belder, B.Lindberg and S.Svensson, Synthesis of Keto-dextrans, Acta Chem. Scand., 1968, 22, 949-952.

6. A.N.de Belder and B.Norrman, The Distribution of substituents in Partially Acetylated Dextran, Carbohyd. Chem., 1968, 8, 1-6.

7. A.N.de Belder and B.Norrman, The Substitution Patterns of O-(2-hydroxyethyl)starch and O-(2-hydroxyethyl)dextran, 1969, 10, 391-394.

8. K.A.Granath, R.Strömberg and A.N.de Belder, Studies on Hydroxyethyl Starch, Die Stärke, 1969, 21, 251-256.

9. A.W.Richter and A.N.de Belder, Antibodies against Hydroxyethylstarch produced in Rabbits by Immunisation with a Protein-Hydroxyethylstarch conjugate, Int.Archs Allergy Appl. Immun., 1976, 52, 307-314.

10. A.N.de Belder and K.Granath, Preparation and Properties of Fluorescein-labelled dextrans, Carbohydr. Chem., 1973, 30, 375-378.

11. A.N.de Belder and K.O.Wik, Preparation and Properties of Fluorescein-labelled hyaluronate, Carbohydr. Chem., 1975, 44, 251-257.

12. A.N.de Belder and E.Wirén, Convenient synthesis of 2-substituted derivatives of methyl alpha-D-glucoside. Carbohyd.Res., 1972, 24, 166-168.

13. L.Ahrgren and A.N.de Belder, The action of Fenton’s reagent on Dextran, Die Stärke, 1975, 27, 121-123.

14. A.N.de Belder, Cyclic acetals of the aldoses and aldosides, in Advances Carbohydr.Chem.,1965, 20, 219-302.

15. A.N.de Belder, Dextran in ‘Industrial Gums’, Academic Press, N.Y. 1993, 399-425.

16. A.N.de Belder, Dextran in ‘Ullman’s Encyclopedia of Industrial Chemistry, Wiley, 2009.

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