Carboxymethyl Dextran

CM-dextran

CM-dextran

CAS Number: 39422-83-8

CM-dextran consists of a dextran backbone substituted with carboxymethyl substituents imparting a polyanionic character to the product. All batches are checked for molecular weight, degree of substitution and loss on drying. TdB labs produce CM-dextrans from 4 kDa to 150 kDa. CM-dextran is supplied as a white powder.

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Structure
Polysucrose is a high molecular weight sucrose-polymer formed by copolymerisation of sucrose with epichlorohydrin. The molecules are highly branched, and the high content of hydroxyl groups leads to very good solubility in aqueous media. In CM-polysucrose, the carboxyl content is approximately 5% which is equivalent to about one CM-group for every five glucose and fructose units.

Storage and stability
CM-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature.

Solubility
CM-dextran dissolves readily in water.

Application
CM-dextran can be used as stabilisers for sensitive biopolymers, as non-toxic ingredients in formulations, as reagents for binding cations (inorganic and organic) via carboxyl reactions and more. Read more about application here.

Click to view publications

  1. Li, B. et al. Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus. Biomaterials 194, 139–150 (2019).
  2. Hwang, H. et al. MESIA: Magnetic force-assisted electrochemical sandwich immunoassays for quantification of prostate-specific antigen in human serum. Analytica Chimica Acta 1061, 92–100 (2019).
  3. Juenet, M. et al. Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156, 204–216 (2018).
  4. Ficko, B. W., NDong, C., Giacometti, P., Griswold, K. E. & Diamond, S. G. A Feasibility Study of Nonlinear Spectroscopic Measurement of Magnetic Nanoparticles Targeted to Cancer Cells. IEEE Transactions on Biomedical Engineering 64, 972–979 (2017).
  5. Burke, M. et al. Regulation of Scaffold Cell Adhesion Using Artificial Membrane Binding Proteins. Macromolecular Bioscience 17, 1600523 (2017).
  6. Terentyeva, T. G. et al. Bioactive flake–shell capsules: soft silica nanoparticles for efficient enzyme immobilization. J. Mater. Chem. B 1, 3248–3256 (2013).
  7. Asgeirsson, D., Venturoli, D., Rippe, B. & Rippe, C. Increased glomerular permeability to negatively charged Ficoll relative to neutral Ficoll in rats. American Journal of Physiology-Renal Physiology 291, F1083–F1089 (2006).

Technical documents

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