Dextran sulfates

About dextran sulfates

Dextran sulfate is an anionic derivative of dextran produced by sulfation of selected dextran fractions. Dextran is a polysaccharide derived from the bacterium Leuconostoc mesenteroides B512F and consists of an α-D-(1 – 6) linear glucan with a low content (ca. 5%) of sidechains linked to the 3-carbon of glucose. We now supply two series of dextran sulfates; one series with high sulfate content (16-20% sulfur) and another series with lower sulfate content (8-13% sulfur).

TdB Labs produce dextran sulfates with a mean molecular weight ranging from 5 kDa to 2000 kDa.

All our dextran sulfates are manufactured by the same process which gives pure white products.

NOTE: we can provide Pharmaceutical grade purity on demand if you aim to use our products as Raw Matrials for the pharmaceutical formulations, medical devices or related. We fullfill requirements from the European Pharmacopoeia (EP) for production and quality for “Dextran for injection” that are in accordance with EDQM certification, including testing for microbial contamination and bacterial endotoxins, sulfated ash, heavy metals and more. Let us know prior to your order if you need PharmaGrade purity.

Products

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High sulfate dextran

CAS Number: 9011-18-1

The degree of sulfatation of our high sulfated dextran sulfates lies between 16 to 20 %. We produce high sulfated dextran sulfates from 5 kDa to 2000 kDa.

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product-dextran-sulfates-2

Low sulfate dextran

CAS Number: 9011-18-1

The sulfate content of our low sulfated dextran sulfates lies between 8 to 13 %. TdB Labs produce low sulfated dextran sulfates from 5 kDa to 500 kDa.

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Applications

Dextran sulfates have a wide range of applications areas and properties. Some examples are:

  • Anti-coagulation agent in cell media
  • Selective precipitation of lipoproteins
  • Acceleration of DNA hybridisation.
  • Releasing DNA from DNA-histones complexes
  • Inhibition tRNA-binding to ribosomes
  • Inhibition of ribonucleases
  • Anti-viral properties
  • Used in cosmetics for anti-inflammation properties and osmotic retention of water
  • Separation of microorganisms and macromolecules
  • Adjuvant in vaccines
  • Studies of perm selectivity of membranes

Dextran sulfate expertise

In need of specialised
expertise in this area?

Contact TdB Labs to be your research partner.

 

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