Dextran sulfate 10 is a low molecular weight dextran derivative produced by sulfation of selected dextran fractions. TdB Labs produce both low sulfated and hight sulfated dextran sulfate 10, where 10 represents a molecular weigh of 10 000 Da. The full name is Dextran sulfate (sulphate) sodium salt 10kDa.
Dextran sulfate 10 from TdB Labs is made by a novel and unique know-how procedure, which gives a white powder with low absorbance and excellent stability. The product does not contain pyridine.
Dextran sulfate 10 is supplied as the sodium salt and is stabilised by a small addition of phosphate salts. The molecular weight refers to values obtained after sulfation. A certificate of analysis is supplied with each batch. The molecular weight range, sulfur content, moisture etc. are carefully controlled.
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Structure Dextran is a polysaccharide derived from the bacterium Leuconostoc mesenteroides B512F and consists of an α-D-(1 – 6) linear glucan with a low content (ca. 5%) of sidechains linked to the 3-carbon of glucose. Dextran sulfate 10 is a sulfated derivative of selected dextran fraction. The sulfate content of our low sulfated dextran sulfate 10 lies between 8 to 13 %, the degree of sulfatation of our high sulfated dextran sulfate 10 is between 16 to 20 %.
Storage and Storage and stability
Dextran sulfate 10 is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature
Dextran sulfate 10 is readily soluble in water.
Dextran sulfate 10 or low molecular weight dextran sulfate sodium salt has a wide range of applications areas and properties.
Dextran sulfate 10 is a common additive in cosmetcs where it is often used as skin-friendly gel-forming agent with moisturizing and water-retaining properties. Dextran sulfate 10 in combination with other anti-coagulants can be use in to diminish cell-aggregation as an additive in cell culture media, similarly as described for DS5 (Jing et al, 2016). Dextran sulfate has also shown to inhibit apoptosis and increase protein production in CHO cells (Menvielle et al, 2013).
Used in cosmetics for anti-inflammation properties and osmotic retention of water
Selective precipitation of lipoproteins
Cell culture media additive against cell clotting
Releasing DNA from DNA-histones complexes
Inhibition tRNA-binding to ribosomes
Inhibition of ribonucleases
Separation of microorganisms and macromolecules
Adjuvant in vaccines
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Ali, H. M. et al. Safety and Clinical Outcomes of Using Low–Molecular-Weight Dextran During Islet Autotransplantation in Children. PancreasPublish Ahead of Print, (9000).
Möhwald, M. et al. Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages. Adv Healthc Mater6, (2017).
Dijk, M. et al. How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure24, 2182–2189 (2016).
Shahraz, A. et al. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Scientific Reports5, 16800 (2015).
Svensjö, E., Nogueira de Almeida, L., Vellasco, L., Juliano, L. & Scharfstein, J. Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2 and B1 Receptors. Mediators of Inflammation https://www.hindawi.com/journals/mi/2014/143450/abs/ (2014) doi:10.1155/2014/143450.
Parraga, J. E., Zorzi, G. K., Diebold, Y., Seijo, B. & Sanchez, A. Nanoparticles based on naturally-occurring biopolymers as versatile delivery platforms for delicate bioactive molecules: An application for ocular gene silencing. International Journal of Pharmaceutics477, 12–20 (2014).
Svensjö, E. et al. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1–CXCR1/2-pathway. Microvascular Research83, 185–193 (2012).
Russo, L. M. et al. Renal Processing of Albumin in Diabetes and Hypertension in Rats. AJN23, 61–70 (2003).
Landauer, K. et al. Influence of Carboxymethyl Dextran and Ferric Citrate on the Adhesion of CHO Cells on Microcarriers. Biotechnology Progress19, 21–29 (2003).
Hugerth, A. M. Micropolarity and Microviscosity of Amitriptyline and Dextran Sulfate/Carrageenan‐Amitriptyline Systems: The Nature of Polyelectrolyte–Drug Complexes. Journal of Pharmaceutical Sciences90, 1665–1677 (2001).
Persson, B., Hugerth, A., Caram-Lelham, N. & Sundelöf, L.-O. Dextran Sulfate−Amphiphile Interaction; Effect of Polyelectrolyte Charge Density and Amphiphile Hydrophobicity. Langmuir16, 313–317 (2000).
Hugerth, A. & Sundelöf, L.-O. Effect of Polyelectrolyte Counterion Specificity on Dextran Sulfate−Amphiphile Interaction in Water and Aqueous/Organic Solvent Mixtures. Langmuir16, 4940–4945 (2000).
Burne, M. J. et al. Anomalous decrease in dextran sulfate clearance in the diabetic rat kidney. American Journal of Physiology-Renal Physiology274, F700–F708 (1998).
Caram‐Lelham, N., Hed, F. & Sundelöf, L.-O. Adsorption of charged amphiphiles to oppositely charged polysaccharides—A study of the influence of polysaccharide structure and hydrophobicity of the amphiphile molecule. Biopolymers41, 765–772 (1997).
Vyas, S. V., Burne, M. J., Pratt, L. M. & Comper, W. D. Glomerular Processing of Dextran Sulfate during Transcapillary Transport. Archives of Biochemistry and Biophysics332, 205–212 (1996).
Wells, X. E. & Dawes, J. Role of the Liver and Kidney in the Desulphation of Heparin in vivo. Thromb Haemost74, 667–672 (1995).
Vyas, S. V., Parker, J.-A. & Comper, W. D. Uptake of dextran sulphate by glomerular intracellular vesicles during kidney ultrafiltration. Kidney International47, 945–950 (1995).
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