Dextran sulfates are produced by sulfation of selected dextran fractions. TdB Labs produce low sulfated dextran sulfates from 5 kDa to 500 kDa.
The dextran sulfate is supplied as the sodium salt and is stabilised by a small addition of phosphate salts. A certificate of analysis is supplied with each batch. The molecular weight range, sulfur content, moisture etc. are carefully controlled.
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Structure Dextran is a polysaccharide derived from the bacterium Leuconostoc mesenteroides B512F and consists of an α-D-(1 – 6) linear glucan with a low content (ca. 5%) of sidechains linked to the 3-carbon of glucose. Dextran sulfate is a sulfated derivative of selected dextran fraction. The sulfate content of our low sulfated dextran sulfates lies between 8 to 13 %.
Storage and Storage and stability
Dextran sulfate is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature
Dextran sulfate is readily soluble in water.
Used in cosmetics for anti-inflammation properties and osmotic retention of water
Separation of microorganisms and macromolecules
Adjuvant in vaccines
Studies of perm selectivity of membranes
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Möhwald, M. et al. Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages. Adv Healthc Mater6, (2017).
Dijk, M. et al. How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure24, 2182–2189 (2016).
Shahraz, A. et al. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Scientific Reports5, 16800 (2015).
Svensjö, E., Nogueira de Almeida, L., Vellasco, L., Juliano, L. & Scharfstein, J. Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2 and B1 Receptors. Mediators of Inflammation https://www.hindawi.com/journals/mi/2014/143450/abs/ (2014) doi:10.1155/2014/143450.
Parraga, J. E., Zorzi, G. K., Diebold, Y., Seijo, B. & Sanchez, A. Nanoparticles based on naturally-occurring biopolymers as versatile delivery platforms for delicate bioactive molecules: An application for ocular gene silencing. International Journal of Pharmaceutics477, 12–20 (2014).
Svensjö, E. et al. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1–CXCR1/2-pathway. Microvascular Research83, 185–193 (2012).
Russo, L. M. et al. Renal Processing of Albumin in Diabetes and Hypertension in Rats. AJN23, 61–70 (2003).
Landauer, K. et al. Influence of Carboxymethyl Dextran and Ferric Citrate on the Adhesion of CHO Cells on Microcarriers. Biotechnology Progress19, 21–29 (2003).
Hugerth, A. M. Micropolarity and Microviscosity of Amitriptyline and Dextran Sulfate/Carrageenan‐Amitriptyline Systems: The Nature of Polyelectrolyte–Drug Complexes. Journal of Pharmaceutical Sciences90, 1665–1677 (2001).
Persson, B., Hugerth, A., Caram-Lelham, N. & Sundelöf, L.-O. Dextran Sulfate−Amphiphile Interaction; Effect of Polyelectrolyte Charge Density and Amphiphile Hydrophobicity. Langmuir16, 313–317 (2000).
Hugerth, A. & Sundelöf, L.-O. Effect of Polyelectrolyte Counterion Specificity on Dextran Sulfate−Amphiphile Interaction in Water and Aqueous/Organic Solvent Mixtures. Langmuir16, 4940–4945 (2000).
Burne, M. J. et al. Anomalous decrease in dextran sulfate clearance in the diabetic rat kidney. American Journal of Physiology-Renal Physiology274, F700–F708 (1998).
Caram‐Lelham, N., Hed, F. & Sundelöf, L.-O. Adsorption of charged amphiphiles to oppositely charged polysaccharides—A study of the influence of polysaccharide structure and hydrophobicity of the amphiphile molecule. Biopolymers41, 765–772 (1997).
Vyas, S. V., Burne, M. J., Pratt, L. M. & Comper, W. D. Glomerular Processing of Dextran Sulfate during Transcapillary Transport. Archives of Biochemistry and Biophysics332, 205–212 (1996).
Wells, X. E. & Dawes, J. Role of the Liver and Kidney in the Desulphation of Heparin in vivo. Thromb Haemost74, 667–672 (1995).
Vyas, S. V., Parker, J.-A. & Comper, W. D. Uptake of dextran sulphate by glomerular intracellular vesicles during kidney ultrafiltration. Kidney International47, 945–950 (1995).
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