DEAE-dextran is a cationic derivative of dextran. IT is produced by introducing cationic (positively charged) diethylaminoethyl groups into selected dextran fractions. All batches are checked for molecular weight, degree of substitution and loss on drying. TdB Labs produce DEAE-dextran from 4 kDa to 2000 kDa. DEAE-dextrans are supplied as a white hygroscopic powder.
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Structure DEAE-dextrans are synthesised from controlled dextran fractions by reacting with DEAE-chloride. The predominant substituent is the single tertiary group (blue) but this may react further to yield a “tandem” group containing a quaternary amine as well as the tertiary amine. A titration curve reveals the proportions (Fig.2 in datafile).
Storage and stability
DEAE-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature.
Solubility DEAE-dextran dissolves readily in water.
DEAE-dextrans are used in various areas, for example as adjuvants for vaccines, in transfection techniques and viral infectivity, and for stabilisation of proteins (enzymes). Read more about application here.
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Li, B. et al. Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus. Biomaterials194, 139–150 (2019).
Antunes, J. C. et al. Core-Shell Polymer-Based Nanoparticles Deliver miR-155-5p to Endothelial Cells. Molecular Therapy – Nucleic Acids17, 210–222 (2019).
Matuszak, J. et al. Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions. Nanotoxicology12, 957–974 (2018).
Matuszak, J. et al. Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing. Nanomedicine11, 597–616 (2016).
Adal, Y., Pratt, L. & Comper, W. D. Transglomerular Transport of DEAE Dextran in the Isolated Perfused Kidney. Microcirculation1, 169–174 (1994).
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