Carboxymethyl-polysucrose (CM-polysucrose) consists of polysucrose (renamed from Ficoll™) substituted with carboxymethyl groups thereby imparting a polyanionic character to the product. TdB Labs produce CM-polysucrose with a mean molecular weight of 70 kDa. All batches are
checked for molecular weight, degree of substitution and loss on drying. CM-Polysucrose is supplied as a white powder.
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Structure Polysucrose is a high molecular weight sucrose-polymer formed by copolymerisation of sucrose with epichlorohydrin. The molecules are highly branched, and the high content of hydroxyl groups leads to very good solubility in aqueous media. In CM-polysucrose, the carboxyl content is approximately 5% which is equivalent to about one CM-group for every five glucose and fructose units.
Storage and stability
CM-polysucrose is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature.
Solubility CM-polysucrose dissolves readily in water.
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Asgeirsson, D., Venturoli, D., Rippe, B. & Rippe, C. Increased glomerular permeability to negatively charged Ficoll relative to neutral Ficoll in rats. American Journal of Physiology-Renal Physiology291, F1083–F1089 (2006).
Koltun, M., Nikolovski, J., Strong, K., Nikolic-Paterson, D. & Comper, W. D. Mechanism of hypoalbuminemia in rodents. American Journal of Physiology-Heart and Circulatory Physiology288, H1604–H1610 (2005).
Landauer, K. et al. Influence of Carboxymethyl Dextran and Ferric Citrate on the Adhesion of CHO Cells on Microcarriers. Biotechnology Progress19, 21–29 (2003).
Guimarães, M. A. M., Nikolovski, J., Pratt, L. M., Greive, K. & Comper, W. D. Anomalous fractional clearance of negatively charged Ficoll relative to uncharged Ficoll. American Journal of Physiology-Renal Physiology285, F1118–F1124 (2003).
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