CM-polysucrose

CM-polysucrose

Carboxymethyl-polysucrose (CM-polysucrose) consists of polysucrose (renamed from Ficoll™) substituted with carboxymethyl groups thereby imparting a polyanionic character to the product. TdB Labs produce CM-polysucrose with a mean molecular weight of 70 kDa. All batches are
checked for molecular weight, degree of substitution and loss on drying. CM-Polysucrose is supplied as a white powder.

Can’t find what you are looking for? We can always produce a customised product for you. Read more here.

Structure
Polysucrose is a high molecular weight sucrose-polymer formed by copolymerisation of sucrose with epichlorohydrin. The molecules are highly branched, and the high content of hydroxyl groups leads to very good solubility in aqueous media. In CM-polysucrose, the carboxyl content is approximately 5% which is equivalent to about one CM-group for every five glucose and fructose units.

Storage and stability
CM-polysucrose is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature.

Solubility
CM-polysucrose dissolves readily in water.

Application
CM-polysucrose is often used in hydrogels. Read more about application here.

References

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  1. Li, B. et al. Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus. Biomaterials 194, 139–150 (2019).
  2. Hwang, H. et al. MESIA: Magnetic force-assisted electrochemical sandwich immunoassays for quantification of prostate-specific antigen in human serum. Analytica Chimica Acta 1061, 92–100 (2019).
  3. Juenet, M. et al. Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156, 204–216 (2018).
  4. Nultsch, K. & Germershaus, O. Silk fibroin degumming affects scaffold structure and release of macromolecular drugs. European Journal of Pharmaceutical Sciences 106, 254–261 (2017).
  5. Käsdorf, B. T. et al. Mucin-Inspired Lubrication on Hydrophobic Surfaces. Biomacromolecules 18, 2454–2462 (2017).
  6. Ficko, B. W., NDong, C., Giacometti, P., Griswold, K. E. & Diamond, S. G. A Feasibility Study of Nonlinear Spectroscopic Measurement of Magnetic Nanoparticles Targeted to Cancer Cells. IEEE Transactions on Biomedical Engineering 64, 972–979 (2017).
  7. Burke, M. et al. Regulation of Scaffold Cell Adhesion Using Artificial Membrane Binding Proteins. Macromolecular Bioscience 17, 1600523 (2017).
  8. Ndong, C. et al. Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo. Int J Nanomedicine 10, 2595–2617 (2015).
  9. Terentyeva, T. G. et al. Bioactive flake–shell capsules: soft silica nanoparticles for efficient enzyme immobilization. J. Mater. Chem. B 1, 3248–3256 (2013).
  10. Asgeirsson, D., Venturoli, D., Rippe, B. & Rippe, C. Increased glomerular permeability to negatively charged Ficoll relative to neutral Ficoll in rats. American Journal of Physiology-Renal Physiology 291, F1083–F1089 (2006).
  11. Koltun, M., Nikolovski, J., Strong, K., Nikolic-Paterson, D. & Comper, W. D. Mechanism of hypoalbuminemia in rodents. American Journal of Physiology-Heart and Circulatory Physiology 288, H1604–H1610 (2005).
  12. Landauer, K. et al. Influence of Carboxymethyl Dextran and Ferric Citrate on the Adhesion of CHO Cells on Microcarriers. Biotechnology Progress 19, 21–29 (2003).
  13. Guimarães, M. A. M., Nikolovski, J., Pratt, L. M., Greive, K. & Comper, W. D. Anomalous fractional clearance of negatively charged Ficoll relative to uncharged Ficoll. American Journal of Physiology-Renal Physiology 285, F1118–F1124 (2003).

Technical documents

How to order

Visit our webshop to see the molecular weights and pack sizes available. Please send an e-mail to order@tdblabs.se if you would like to receive a quote, place a bulk order or if you wish to place your order manually.

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